Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease.
نویسندگان
چکیده
Partially reduced oxygen species (PROS), produced by reduced heme bound Aβ peptides, can cause oxidative stress and synaptic damage in the brain, which is one of the key pathological features of Alzheimer's disease. In situ oxidation of the heme center by a physiological redox agent like Cytochrome c (Cyt c) can significantly suppress neurotoxic PROS formation. Thus, Cyt c can potentially act as a neuroprotective agent against AD.
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عنوان ژورنال:
- Chemical communications
دوره 49 51 شماره
صفحات -
تاریخ انتشار 2013